Wild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses.
Identifieur interne : 001C22 ( Main/Exploration ); précédent : 001C21; suivant : 001C23Wild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses.
Auteurs : K Y Yuen [République populaire de Chine] ; S K P. Lau ; P C Y. WooSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2012.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN, Animaux, Chiroptera (virologie), Coronavirus (génétique), Coronavirus (isolement et purification), Gènes pol, Génome viral, Hong Kong, Humains, Macaca mulatta (virologie), Phylogénie, RT-PCR, Rodentia (virologie), Réservoirs d'agents pathogènes, Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
- MESH :
- génétique : Coronavirus, Virus du SRAS.
- isolement et purification : Coronavirus, Virus du SRAS.
- virologie : Chiroptera, Macaca mulatta, Rodentia.
- Analyse de séquence d'ADN, Animaux, Gènes pol, Génome viral, Hong Kong, Humains, Phylogénie, RT-PCR, Réservoirs d'agents pathogènes.
- Wicri :
- geographic : Hong Kong.
English descriptors
- KwdEn :
- Animals, Chiroptera (virology), Coronavirus (genetics), Coronavirus (isolation & purification), Disease Reservoirs, Genes, pol, Genome, Viral, Hong Kong, Humans, Macaca mulatta (virology), Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Rodentia (virology), SARS Virus (genetics), SARS Virus (isolation & purification), Sequence Analysis, DNA.
- MESH :
- geographic : Hong Kong.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : Coronavirus, SARS Virus.
- virology : Chiroptera, Macaca mulatta, Rodentia.
- Animals, Disease Reservoirs, Genes, pol, Genome, Viral, Humans, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA.
Abstract
1. Although CoV-HKU1 was not identified in any of the studied animals, a coronavirus closely related to SARS-CoV (bat-SARS-CoV) was identified in 23 (19%) of 118 wild Chinese horseshoe bats by reverse transcriptase polymerase chain reaction (RT-PCR). 2. Complete genome sequencing and phylogenetic analysis showed that bat-SARS-CoV formed a distinct cluster with SARS-CoV as group 2b coronaviruses, distantly related to known group 2 coronaviruses. 3. Most differences between the bat-SARS-CoV and SARS-CoV genomes were observed in the spike gene. The presence of a29-bp insertion in ORF 8 of bat-SARS-CoV genome, not in most human SARS-CoV genomes, suggests that it has a common ancestor with civet SARS-CoV. 4. Antibody against recombinant bat-SARS-CoV nucleocapsid protein was detected in 84% of Chinese horseshoe bats using an enzyme immunoassay.Neutralising antibody to human SARS-CoV was also detected in those with lower viral loads.5. This study also revealed a previously unknown diversity of coronaviruses in bats, which are important natural reservoir for coronaviruses including SARS-CoV-like viruses.
PubMed: 22311357
Affiliations:
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Le document en format XML
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Queen Mary Hospital, Hong Kong SAR, China. hkumicro@hkucc.hku.hk</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong. Queen Mary Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name></author><author><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name></author></analytic><series><title level="j">Hong Kong medical journal = Xianggang yi xue za zhi</title><idno type="ISSN">1024-2708</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chiroptera (virology)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Disease Reservoirs</term><term>Genes, pol</term><term>Genome, Viral</term><term>Hong Kong</term><term>Humans</term><term>Macaca mulatta (virology)</term><term>Phylogeny</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Rodentia (virology)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Chiroptera (virologie)</term><term>Coronavirus (génétique)</term><term>Coronavirus (isolement et purification)</term><term>Gènes pol</term><term>Génome viral</term><term>Hong Kong</term><term>Humains</term><term>Macaca mulatta (virologie)</term><term>Phylogénie</term><term>RT-PCR</term><term>Rodentia (virologie)</term><term>Réservoirs d'agents pathogènes</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Macaca mulatta</term><term>Rodentia</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Macaca mulatta</term><term>Rodentia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Reservoirs</term><term>Genes, pol</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Gènes pol</term><term>Génome viral</term><term>Hong Kong</term><term>Humains</term><term>Phylogénie</term><term>RT-PCR</term><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Although CoV-HKU1 was not identified in any of the studied animals, a coronavirus closely related to SARS-CoV (bat-SARS-CoV) was identified in 23 (19%) of 118 wild Chinese horseshoe bats by reverse transcriptase polymerase chain reaction (RT-PCR). 2. Complete genome sequencing and phylogenetic analysis showed that bat-SARS-CoV formed a distinct cluster with SARS-CoV as group 2b coronaviruses, distantly related to known group 2 coronaviruses. 3. Most differences between the bat-SARS-CoV and SARS-CoV genomes were observed in the spike gene. The presence of a29-bp insertion in ORF 8 of bat-SARS-CoV genome, not in most human SARS-CoV genomes, suggests that it has a common ancestor with civet SARS-CoV. 4. Antibody against recombinant bat-SARS-CoV nucleocapsid protein was detected in 84% of Chinese horseshoe bats using an enzyme immunoassay.Neutralising antibody to human SARS-CoV was also detected in those with lower viral loads.5. This study also revealed a previously unknown diversity of coronaviruses in bats, which are important natural reservoir for coronaviruses including SARS-CoV-like viruses.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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